个人简介：
张永杰，博士，讲师，硕士研究生导师。2018年于荷兰阿姆斯特丹自由大学分子毒理学（Molecular Toxicology）研究室获得博士学位后，入职太阳集团城娱8722临床药学系临床药物代谢动力学研究室任专职教师。
主持国家自然科学基金青年项目1项，江苏省自然科学基金青年项目1项，中央高校基本科研业务费重点项目1项。累计发表SCI研究论文30余篇，其中第一作者或通讯作者14篇；授权专利2项。担任J Agric Food Chem., Int J Biol Macromol., Toxicology等杂志审稿人；兼任日本金泽大学纳米生命科学研究所客座助理教授。主讲《生物药剂学与药物动力学》及实验、《临床药物代谢动力学》及实验、《药物基因组学与遗传学》等课程。
研究方向：
1. 创新药物的药代动力学研究；
2. 代谢酶调控的药物毒性反应及其机制研究；
3. 代谢酶调控的蛋白质后修饰过程及其病理、毒理学意义。
代表性科研论文：
1. Zhang J #; Qiu Z #; Zhang Y #; Wang G *; Hao H *; Intracellular spatiotemporal metabolism in connection to target engagement., Advanced Drug Delivery Reviews, 2023, 200:115024.
2. Huang H; Zhao Y; Huang C; Lv N; Zhao J; Sun S; Guo C; Zhao D; Chen X*; Zhang Y*; Unraveling a Combined Inactivation Mechanism of Cytochrome P450s by Genipin, the Major Reactive Aglycone Derived from Gardeniae Fructus., Chemical Research in Toxicology, 2023, 36(9): 1483-1491.
3. Chen X; Han L; Zhao Y; Huang H; Pan H; Zhang C; Chen H; Sun S; Yao S*; Chen X*; Zhang Y*;Mechanistic Study of Icaritin-Induced Inactivation of Cytochrome P450 2C9., Drug Metabolism and Disposition, 2023, 51(6):771-781.
4. Zhao Y; Huang H; Lv N; Huang C; Chen H; Xing H; Guo C; Li N; Zhao D; Chen X*; Zhang Y*; Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism., Journal of Agricultural and Food Chemistry, 2023, 71(5):2399-2410.
5. Li Y; Sun C; Zhang Y; Chen X; Huang H; Han L; Xing H; Zhao D; Chen X*; Zhang Y*; Phase I Metabolism of Pterostilbene, a Dietary Resveratrol Derivative: Metabolite Identification, Species Differences, Isozyme Contribution, and Further Bioactivation., Journal of Agricultural and Food Chemistry, 2023, 71(1):331-346.
6. Zhang Y #*; den Braver-Sewradj SP #; den Braver MW; Hiemstra S; Vermeulen NPE; van de Water B; Commandeur JNM; Vos JC; Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells., Frontiers in Pharmacology, 2018, 9:388.
7. Zhang Y; den Braver-Sewradj SP; Vos JC; Vermeulen NPE; Commandeur JNM *; Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity., Toxicology Letters, 2017, 275: 83-91.
8. Zhang Y; Vermeulen NPE; Commandeur JNM *; Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine, British Journal of Clinical Pharmacology, 2017.3, 83(3): 572-583.
联系方式：
通信地址：南京市江宁区龙眠大道639号，太阳集团tcy8722医学楼223室
电话：025-86185379
邮箱：zhangyongjie@cpu.edu.cn; zhangyongjie1989@hotmail.com